Endocrine Abstracts

Introduction: IgG4-related disease is a newly recognized entity associated with autoimmune conditions involving almost every organ system, characterized by elevated serum IgG4 as well as mass like tissue infiltration by IgG4-positive plasma cells. Pituitary gland can be involved and can presented as hypophysitis.Case description: We report a case of a 56-year-old man, who has been suffering for the nine last years of episodes of fatigue and headaches wit...

Background: Prolactinomas are the most common hormone-secreting pituitary tumors and are a common cause of anovulation and infertility. Giant prolactinomas (0.5–4.4% of all pituitary tumors) are rare tumors characterized by their large size (>4 cm), compressive symptoms and extremely high prolactin secretion (>1000 ng/ml). Men are most commonly affected, with a reported male to female ratio of 9:1.Case report: We present the rare case of 53-...

Background: Selenium (Se), a trace mineral with anti-oxidative properties, has been proposed to be potentially beneficial in patients with Graves’ disease (GD), especially those with active Graves’ ophthalmopathy (GO).Methods: Trials evaluating the efficacy of Se among non-pregnant adult GD patients with active GO, versus either placebo or an alternative drug, and on top of standard therapy, were included. A literature search was performed by t...

There are growing evidences suggesting the existence of intra-tumor heterogeneity within the same patient, leading to a different genetic pattern between primary tumour and metastases.We report a paradigmatic example of genetic heterogeneity in thyroid cancer (TC). A 42 years old female patient was submitted, for a follicular TC, to total thyroidectomy and lymphadenectomy followed by radioiodine residue ablation in late 1999. In 2000 and 2001 diagnostic ...

Background: OPKO Biologics is a clinical-stage public company developing long-acting therapeutic proteins utilizing CTP technology. The technology involves fusion of the C-terminal peptide of human chorionic gonadotropin (hCG), which is highly O-glycosylated, to the target protein. CTP enabled the production of a long-acting human growth hormone (hGH) (MOD-4023), which supports a single weekly injection in growth hormone-deficient patients. MOD-4023 is manufactured as a non-vi...

One of the main consequences of vessel pruning and inhibition of neovessel growth produced by angiogenesis inhibitors is increased intra-tumor hypoxia. Nevertheless, growing evidence indicates that tumor cells escape from this hypoxic environment to better nourished locations, presenting hypoxia as a positive stimulus for invasion. Indeed, we and others have described a pro-invasive and pro-metastatic adaptation to VEGFR-targeted antiangiogenic therapy that implicates hypoxia ...

Introduction: Children with TPS and/or ICDI represent a diagnostic and management conundrum. Agreed radiological criteria for TPS are lacking.Aims: To longitudinally characterize the neuroradiological features of children presenting with TPS and/or ICDI due to different aetiologies (oncological, inflammatory, idiopathic).Methods: We searched the terms ‘thickened pituitary stalk’ or ‘idiopathic diabetes insipidus&#146...

Elongation factor, RNA polymerase II, 2 (ELL2) is an RNA Pol II elongation factor with functional properties similar to ELL that can interact with the prostate tumor suppressor ELL-associated factor 2 (EAF2). In murine models, deletion of Ell2 induced prostate intraepithelial neoplasia similar to that induced by deletion of Eaf2. Since ELL2 and EAF2 can functionally interact and appear to have similar function in regulating prostate homeostasis, we investigated the impact of c...

Patient is a seventy year old Egyptian female with past medical history of coronary artery disease, systolic heart failure, chronic kidney disease stage 3, and a benign pheochromocytoma previously worked up at a neighboring hospital, who was admitted for dyspnea and subjective fever intermittently for the past two weeks. Chest x-ray revealed bilateral pulmonary infiltrates. She was treated for community acquired pneumonia. Four days after admission patient has worsening respir...

Traditionally, oestradiol measurement is performed by immunoassay. The sensitivity of these assays is not sufficiently sensitive for certain patient groups such as males, post-menopausal females and children. There is also a potential for interference from structurally related compounds or heterophilic antibodies. LC–MS/MS is an attractive alternative as it has increased sensitivity and specificity.We reviewed the requests for LC–MS/MS analysis...